Search results for "Follicular hyperplasia"
showing 3 items of 3 documents
Neurofilament is an autoantigenic determinant in myasthenia gravis
1999
Intratumorous expression of a 153-kd protein (p153), which contains an acetylcholine receptor-like epitope, is the only tumor marker described to date that significantly associates with thymoma in paraneoplastic myasthenia gravis (MG). Here, we report that p153 is identical to the midsize neurofilament, as verified by immunohistochemistry, immunofluorescence, and western blot analysis. Furthermore, the acetylcholine receptor-like epitope of the midsize neurofilament (NF-M) was identified by peptide epitope mapping. We also show, using T-cell proliferation assays, a significantly increased response of intratumorous T cells to a recombinant midsize neurofilament fragment in thymoma patients w…
Parotid lymphoepithelial cyst in non-HIV patient
2011
The lymphoepithelial cyst is a dysontogenic benign cyst originated from the epithelial remnant retained inside the lymphoid tissue during the embryogenesis that occurs in the lateral neck region and, less frequently, in the oral cavity and in the parotid gland. The parotid gland evolvement increased significantly after the HIV discovery and it is related to ductal obstruction phenomenon that goes along with a follicular hyperplasia in the periductal parotid lymph nodes. However, lymphoepithelial cysts are rare in non-HIV patients. Treatment options are controversial and might include cystic content aspiration, sclerosis-therapy, radiotherapy and surgery. Enucleation of the cyst while preser…
The Man Behind the Eponym: Hans Biberstein and Follicular Hyperplasia Overlying Dermatofibroma
2009
Hans Biberstein first described the basaloid follicular hyperplasia overlying dermatofibromas in 1923 and published his extensive observations on the subject in 1931. Part of Josef Jadassohn's department in Breslau, he was forced to leave German by the National Socialist regime and spent the rest of his career in New York. After a hiatus of 30 years, the dermatopathologic literature once again began addressing his seminal finding but never gave him proper credit. We suggest Biberstein's sign as an appropriate term for basaloid follicular hyperplasia overlying a dermatofibroma and as a small tribute to a pioneer dermatopathologist.